Evaluation of New Binder Isolated from Tinospora cordifolia for the Preparation of Paracetamol Tablets

Pharmaceutical Manufacturing is an important enterprise and oral tablet manufacturing is the most significant of all, because more drugs are made as tablets than any other dosage form. The way of tablet manufacturing has been undergoing change in recent years and is likely to head in new directions. In this study Tinospora cordifolia (guduchi) a freely available, a climbing shrub belonging to the family Menispermaceae, a cheap source of starch has been chosen for isolation of starch (binder) and used for the preparation of paracetamol model drug. The tablets were prepared by wet granulation method using 4% w/v, 6% w/v, 8% w/v, 10% w/v and 12% w/v of Tinospora cordifolia starch and compared with maize starch (Standered) as binding agent. All the paracetamol tablets were evaluated for weight variation, hardness, friability, disintegration time and invitro drug release etc. The study results indicate the tablet with higest binder concentration showed maximun hardness and disentigration time and minimum friability compared with standard binder.